CEREBRAL CIRCULATION

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Abstract
During the last four years there has appeared from this laboratory a series of studies on cerebral circulation.1Many of these studies have been made by means of a cranial window which enables the investigator to make direct observations on the caliber of the pial arteries and veins and on the stream of blood flowing through them. Consistent results have been obtained in studying the effect on the pial arteries of sympathetic and vagus stimulation, hypertonic solutions, carbon dioxide and oxygen, histamine, acetylcholine, amyl nitrite and caffeine. These observations have been limited to measurements of the diameter of the pial vessels, and deductions have been drawn from these observations as to the flow of blood through the pial arteries. The experiments presented here deal with an attempt at measuring directly the minute volume cerebral flow of blood by a perfusion method in cats and monkeys during various experimental conditions.

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