AMINO-TERMINAL SEQUENCE OF A CARCINOEMBRYONIC ANTIGEN-LIKE GLYCOPROTEIN ISOLATED FROM COLONIC LAVAGES OF HEALTHY INDIVIDUALS

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 38  (3) , 503-505
Abstract
A glycoprotein was isolated from the colonic lavages of healthy individuals that is immunologically equivalent to carcinoembryogenic antigen purified from tumor tissue. The NH2-terminal sequence of the glycoprotein from normal colon lavages is Lys-Leu-Thr-Ile-Glu-Ser-Thr-Pro-Phe-(Asn)-Val-Ala-Glu-Gly-Lys-Glu-Val-(Leu,Ile)-(Leu,Ile)-(Leu,Ile)-Val-(His,Arg?)-?-(Leu,Ile). This is homologous to the NH2-terminal sequence of 23 of the first 24 amino acids of carcinoembryonic antigen isolated from tumor tissue.