Toxic and DNA‐damaging activities of the fungicides mancozeb and thiram (TMTD) on human lymphocytes in vitro
- 1 January 1989
- journal article
- research article
- Published by Wiley in Teratogenesis, Carcinogenesis, and Mutagenesis
- Vol. 9 (2) , 75-81
- https://doi.org/10.1002/tcm.1770090203
Abstract
The cytotoxic and mutagenic effects of the fungicides mancozeb and thiram were studied using human peripheral blood lymphocytes cultured in vitro with or without an S-9 mix microsomal metabolizing system. The results obtained suggested that the chemicals caused dose-dependent inhibition of thymidine uptake and unscheduled DNA synthesis on both resting and proliferating lymphocytes in the absence of the S-9 mix. In the presence of the S-9 mix, only thiram showed mutagenic activity by eliciting unscheduled DNA synthesis and a significantly higher frequency of sister chromatid exchanges than did controls.Keywords
This publication has 17 references indexed in Scilit:
- Teratogenic evaluation of mancozeb in the rat following inhalation exposureToxicology and Applied Pharmacology, 1986
- Structure-genotoxic activity relationships of pesticides: comparison of the results from several short-term assaysMutation Research/Environmental Mutagenesis and Related Subjects, 1985
- Enzyme inhibition as a possible mechanism of the mutagenicity of dithiocarbamic acid derivatives in Salmonella typhimuriumChemico-Biological Interactions, 1984
- Further mutagenicity studies on pesticides in bacterial reversion assay systemsMutation Research/Genetic Toxicology, 1983
- Cytogenetic effects of alachlor and mancozebMutation Research/Genetic Toxicology, 1983
- Microbial short-term assays with thiram in vitroMutation Research/Genetic Toxicology, 1981
- Non-mutagenicity of the fungicide dithane M-45 as inducer of recessive lethals after larval feeding in Drosophila melanogasterMutation Research/Genetic Toxicology, 1980
- Mutagenic activity of thiram in ames tester strains of Salmonella typhimuriumMutation Research/Genetic Toxicology, 1979
- Mutagenicity screening of pesticides in the microbial systemMutation Research/Genetic Toxicology, 1976
- Genetic effects of fungicidesMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1970