INCREASE IN THE BETA SUBUNIT OF HUMAN TSH IN HYPOTHYROID SERUM AFTER THYROTROPIN RELEASING HORMONE1
- 1 November 1973
- journal article
- other
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 37 (5) , 836-840
- https://doi.org/10.1210/jcem-37-5-836
Abstract
The beta subunit of human thyrotropin (hTSH-β) was detected in the serum of 9 of 11 patients with primary hypothyroidism. After the administration of thyrotropin releasing hormone (TRH), there was an increase in serum hTSH-β in all 11 patients. Five of the patients studied at multiple intervals after TRH showed an increase in hTSH-β as early as 5 minutes after TRH. HTSH-β rose more rapidly and reached a peak earlier than hTSH. The data suggest that hTSH-β is secreted in response to TRH in patients with primary hypothyroidism.Keywords
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