An immobilized cell culture system for berberine production by Thalictrum minus cells
- 1 June 1987
- journal article
- research article
- Published by Springer Nature in Plant Cell Reports
- Vol. 6 (3) , 185-186
- https://doi.org/10.1007/bf00268474
Abstract
Thalictrum minus cells immobilized in calcium-alginate beads were cultured in a newly devised bioreactor for the purpose of producing berberine. This system could prevent cells from leaking out of the beads, allowing them to release most of the berberine synthesized into the liquid medium. Furthermore, the biosynthetic capability of the immobilized cells was found to be comparable to that of freely suspended cells.Keywords
This publication has 4 references indexed in Scilit:
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- Release and crystallization of berberine in the liquid medium of Thalictrum minus cell suspension culturesPlant Cell Reports, 1984
- The immobilization of microbial cells, subcellular organelles, and enzymes in calcium alginate gelsBiotechnology & Bioengineering, 1977