THE EFFECT OF RENIN ON THE URIC ACID METABOLISM OF THE PREGNANT AND NONPREGNANT DALMATIAN DOG1

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Abstract
Single injs. of renin in. the pregnant and non-pregnant Dalmatian dog raised the uric acid excretion 31 to 190% and the blood uric acid 23 to 60%. Repeated injs. over a period of 4 days produced a continued rise in the daily uric acid excretion, reaching 97% above the initial excretion, whereas the blood uric acid was only temporarily raised after each inj. Exptl. hypertension in a pregnant Dalmatian dog produced a sustained elevation in the blood uric acid level to as high as 81% and averaging 56% without affecting the blood non-protein N except post-operatively. The blood sugar rose 17% after single renin. injs. In the hypertensive pregnant dog a sustained hyper-glycemia was obtained with a maximal rise of 41% and an avg. rise of 27%.