ULTRASTRUCTURE AND VIABILITY OF ESCHERICHIA-COLI TREATED WITH FOSFOMYCIN

  • 1 January 1979
    • journal article
    • research article
    • Vol. 245  (1-2) , 48-54
Abstract
In concentrations of 6 .mu.g/ml and 60 .mu.g/ml fosfomycin was bactericidal against E. coli ATCC 10536. The sensitivity of E. coli was evaluated by turbidity measurement and by counting colony forming units (CFU). The bactericidal action began at different times in respect to the concentration and the method of documentation: turbidity fell 30-120 min after the administration of 6 .mu.g/ml and 10-30 min after 60 .mu.g/ml; CFU were reduced 10-30 min after 6 .mu.g/ml and 3-10 min after 60 .mu.g/ml. Before the cytoplasm and DNA region were disorganized with reduced electron density, some elongated (up to more than 20 .mu.m) cells occurred. More prominent alterations in shape and ultrastructure were obvious 120 min after 6 .mu.g/ml and after 30 min when 60 .mu.g fosfomycin/ml were administered.

This publication has 0 references indexed in Scilit: