THE HEART RATE AFTER SYMPATHECTOMY AND VAGOTOMY AND THE BLOOD SUGAR AS AFFECTED BY POSTERIOR HYPOPHYSEAL EXTRACTS (PITRESSIN AND PITOCIN)

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Abstract
In 6 normal cats pitressin, injected intravenously, caused a prompt reduction in heart rate (confirming Gruber''s observations). In 4 normal cats pitocin had little effect. In 4 surviving vagotomized cats, pitressin reduced the heart rate, but to a level still far above the average basal rate for a normal animal. In cats surviving excision of both sympathetic chains, the action of pitressin upon heart rate was dependent upon the presence or absence of (central) vagus innervation to the heart. Slowing occurs when the vagi are present [2 cats]; marked acceleration when these nerves have been sectioned [4 cats]. Both pitressin and pitocin, given intravenously [to 6 normal cats], caused a prompt rise in blood-sugar concentration. The hyperglycemia may last as long as 2 hrs. In 5 sympathectomized cats the glycemic effect of pitressin was somewhat less than in normal animals, but not markedly so.

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