Effect of Fc-Receptor Modulation on Mumps-Virus-dependent Lymphocyte-mediated Cytotoxicity in Vitro

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Abstract
The natural cytotoxicity of peripheral blood lymphocytes (PBL) from normal human donors to a variety of tissue culture target cells increases upon brief exposure of lymphocytes to mumps virus. The effector cells operative in this system have Fc receptors for Ig[immunoglobulin]G (FcR), since cytotoxicity was abolished when FcR+ cells were removed by passage of the lymphocytes over immune complex columns. When PBL were treated with immune complexes for 16 h at 37.degree. C, their FcR activity was sharply decreased (modulation), as indicated by a significantly reduced capacity of the treated cells to display antibody-dependent cytotoxicity. Modulation had variable effects on natural cytoxicity. The virus-dependent cytoxicity above the natural cytotoxicity remained essentially unchanged, indicating that a functionally intact FcR is not required in this system for carrying out cytolysis.