Early Changes Induced in Rat Liver by Methylazoxymethanol Acetate: Mitotic Abnormalities and Polyploidy2

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Abstract
Within 24–48 hours after a single dose of methylazoxymethanol (MAM) acetate, the livers of rats showed extensive hemorrhage and necrosis; however, by the 4th day the liver showed little pathology other than irregularities in the size and shape of the hepatocytes. Significantly increased thymidine incorporation into hepatic DNA at this time, relative to controls, suggested that the replacement of necrotic cells was not yet complete. Seven days after treatment, when DNA synthesis had returned to control levels, the number of polyploid cells increased significantly. In addition, ≈ 11% of the hepatocyte anaphase and telophase mitotic figures contained chromosomal bridges and acentric fragments. The mitotic abnormalities and the increase in polyploid cells were evident as late as 1 month after treatment.

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