A FAMILY STUDY OF SPONTANEOUS SISTER CHROMATID EXCHANGE FREQUENCY
- 1 January 1982
- journal article
- research article
- Vol. 34 (2) , 294-306
Abstract
The frequency of spontaneos sister chromatid exchanges (SCE) was determined in PHA-[phytohemagglutinin]-stimulated peripheral lymphocytes of 52 individuals, comprising 12 complete 2-generation pedigrees. Neither intraindividual variation between replicate cultures established from the same blood sample nor variation among samples from the same individual initiated at different times was significant. Familial factors affecting mean SCE frequencies were indicated by detection of significant differences among, but not within families. Although sample sizes were small, a genetic contribution to the SCE frequency was suggested by the observed pattern of familial correlations.This publication has 34 references indexed in Scilit:
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