The Response of Infants and Children to Muscle Relaxants

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Abstract
The respiratory response of infants and children to d-tubocurarine and succinylcholine was examined. Under halothane anesthesia children under one year require about one quarter of the dose of d-tubocurarine/kg of body weight compared to children over 12 years. The variation in the amount of respiratory depression caused by d-tubocurarine at different ages depends upon the general anesthetic agent used. Succinylcholine, with halothane anesthesia, produced greater relaxation in children under one year than in older children. It appeared that children under one year are more sensitive to the drug.

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