Carboplatin-Radiation Interaction in Squamous Cell Carcinoma Cell Lines
- 1 December 1992
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA Otolaryngology–Head & Neck Surgery
- Vol. 118 (12) , 1312-1315
- https://doi.org/10.1001/archotol.1992.01880120038007
Abstract
• Chemoradiotherapy has been considered one of the most promising improvements in the treatment of advanced head and neck cancer. This article describes in vitro chemosensitivity to carboplatin in five squamous cell carcinoma cell lines established from head and neck cancers and in one vulvar squamous cell carcinoma cell line. Sensitivity to carboplatin was found to vary markedly when using the 96-well plate clonogenic assay and continuous drug exposure. The difference in carboplatin response between the most sensitive and the most resistant cell lines was fourfold. No cross-resistance was observed between inherent radiosensitivity and chemosensitivity. Effects of concomitant use of carboplatin and radiation were further investigated in the two cell lines that were found to be most sensitive to carboplatin. The drug was administered 1 hour before acute radiation doses, and an additive effect was observed in both cell lines. (Arch Otolaryngol Head Neck Surg. 1992;118:1312-1315)Keywords
This publication has 19 references indexed in Scilit:
- Locally advanced paranasal sinus and nasopharynx tumors treated with hyperfractionated radiation and concomitant infusion cisplatinCancer, 1991
- Phase I study of concurrent carboplatin and radiotherapy in previously untreated patients with stage III and IV head and neck cancerHead & Neck, 1991
- The Independent Action of Radiation and Cisplatin on the Survival or Recovery of Human Normal or Tumour Cellsin Vitroorin VivoInternational Journal of Radiation Biology, 1989
- Simultaneous Radiation Therapy and Cisplatin Chemotherapy in Advanced Cancer of the Head and Neck A Pilot Study at Tygerberg Hospital, Parowvallei, South AfricaAmerican Journal of Clinical Oncology, 1987
- Radiosensitization in vitro by cis-diammine(1,1-cyclobutanedicarboxylato) platinum(II) (carboplatin, JM8) and ethylenediammine-malonatoplatinum(II) (JM40)Radiotherapy and Oncology, 1987
- Cisplatin Sensitization to Radiotherapy in Stage IV Squamous Cell Carcinoma of the Head and Neck: A Follow-up ReportJAMA Otolaryngology–Head & Neck Surgery, 1986
- Enhancement of radiation-induced cell kill by platinum complexes (carboplatin and iproplatin) in V79 cellsInternational Journal of Radiation Oncology*Biology*Physics, 1986
- Enhancement of the responses of human colon adenocarcinoma cells to X-irradiation and cis-platinum by N-methylformamide (NMF)International Journal of Radiation Oncology*Biology*Physics, 1985
- Carboplatin as a potentiator of radiation therapyCancer Treatment Reviews, 1985
- Cisplatin Potentiation of Radiotherapy: Long-term Follow-upJAMA Otolaryngology–Head & Neck Surgery, 1985