Betulinic Acid Inhibits Aminopeptidase N Activity

1 October 1998

journal article
letter
Published by Georg Thieme Verlag KG in Planta Medica

Vol. 64 (07) , 655-657
https://doi.org/10.1055/s-2006-957542

Abstract

The triterpene betulinic acid inhibits the activity of aminopeptidase N (EC 3.4.11.2) in a dose-dependent manner. An IC₅₀ of 7.3±1.4 µM was determined for betulinic acid. This inhibitory activity is higher than that of bestatin (IC₅₀ = 16.9±4.1 µM), a well known inhibitor of this enzyme. The finding supports the idea that betulinic acid acts as anti-melanoma agent via inhibition of aminopeptidase N activity.

Keywords

ACID INHIBITS
BETULINIC ACID
MELANOMA
BESTATIN
TRITERPENE
INHIBITORY
INHIBITION OF AMINOPEPTIDASE

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