How an acute rise in arterial pressure damages arterioles: Electron microscopic changes during angiotensin infusion

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Abstract
Angiotensin infusion was used to cause a sustained rise in arterial pressure in rats. After 1 hr of raised pressure electron microscopy of segments of gut arterioles showed focal breaks in the endothelium and amorphous deposits in the media displacing and disrupting smooth muscle cells. Intravenously injected carbon particles were found in the amorphous deposits, sometimes in relation to electron-dense material resembling fibrin. The damage was patchy and confined to dilated segments of arterioles. These appearances were consistent with the passage of plasma into the media through the damaged endothelium as a consequence of the raised arterial pressure.

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