Risk of Venous Thrombosis With Use of Current Low-Dose Oral Contraceptives Is Not Explained by Diagnostic Suspicion and Referral Bias
Open Access
- 11 January 1999
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 159 (1) , 65-70
- https://doi.org/10.1001/archinte.159.1.65
Abstract
SEVERAL developments have generated renewed interest in the risk of venous thromboembolism associated with the use of oral contraceptives.1 Results of recent large case-control studies2-5 in different parts of the world show that the relative risk of venous thromboembolism associated with low-dose oral contraceptive use is still elevated 3- to 4-fold. The risk is reported3-6 to be even higher for use of preparations containing newer progestins. In addition, females who carry the factor V Leiden mutation and use oral contraceptives have a venous thrombosis risk that might be elevated 30-fold or more7 compared with nonusers without such a mutation.This publication has 2 references indexed in Scilit: