Bulimia treated with imipramine: a placebo-controlled, double-blind study

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Abstract
Bulimia, the syndrome of compulsive binge eating, is a common and often severe disorder frequently resistant to known therapies. Recent evidence suggesting a link between bulimia and affective disorder prompted performance of a double-blind study of imipramine vs. placebo with 22 chronically bulimic women. Imipramine was associated with a significantly reduced frequency of binge eating and improvement on several other measures of eating behavior. On 1-8 mo. follow-up, 18 of the 20 treated subjects (90%) responded to imipramine or a subsequent antidepressant. The growing evidence that bulimia may be related to affective disorder was augmented.