The positions of the centromeres in linkage groups II and IX of the mouse
- 14 April 1968
- journal article
- research article
- Published by Hindawi Limited in Genetics Research
- Vol. 11 (2) , 193-199
- https://doi.org/10.1017/s0016672300011368
Abstract
In mice heterozygous for translocation T(2;?)163H, and also for linkage group II markers, the cw locus shows close linkage with the point of rearrangement (about 1−2% recombination). Since T 163 was apparently formed by fusion of two chromosomes near their centromeres, this means that the centromere must lie at the cw end of linkage group II. In homozygotes for T(2; 9)138Ca the genes T and d show significant linkage, indicating that their loci are on opposite sides of the trans-location break. Since, from previous data, the break is known to be proximal to d, it must then be distal to T and, again from previous data, the order of loci hi linkage group IX must be centromere-T-tf-T 138 break.Keywords
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