A hypothesis to explain the enigmatic natural history of neuroblastoma
- 1 January 1984
- journal article
- research article
- Published by Wiley in Medical and Pediatric Oncology
- Vol. 12 (1) , 64-67
- https://doi.org/10.1002/mpo.2950120115
Abstract
A hypothesis is developed for neuroblastoma that attempts to explain the enigmatic natural history of this tumor and the variation in success of therapy as a function of the age of the child at diagnosis. It is postulated that neuroblastoma arising in the young patient has a relative paucity of clonogenically viable stem cells, whereas tumors arising in the older children have a substantial number of such clonogenic cells, as in most human tumors.Keywords
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