Continuous RBC transfusions in a patient with sickle cell disease
- 1 February 1982
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 142 (2) , 279-282
- https://doi.org/10.1001/archinte.142.2.279
Abstract
A patient with severe sickle cell anemia received approximately 600 RBC [red blood cell] transfusions during a period of 30 yr. Continuous prophylactic transfusions were administered for 13 yr. During the 13-yr period, except for tissue damage already inflicted by sickle cell disease, she was free of symptoms. When a Hb concentration of 12 g/dl was maintained, she had ineffective erythropoiesis postulated to be due to the inability of her reticulocytes to cross the sinusoidal barrier from marrow to blood. Up to the time of her death at the age of 47 yr, there was no evidence that her massive Fe overload produced clinical symptoms other than those related to osteoporosis. The cause of her death was unexplained, although her massive Fe overload remains suspect.This publication has 1 reference indexed in Scilit:
- Symptomatic Crises of Sickle Cell Anemia Treated by Limited Exchange TransfusionAnnals of Internal Medicine, 1970