Improvement in the sensitivity of DNA polymerase I-deficient Escherichia coli for detecting mutagens and carcinogens
- 1 December 1978
- journal article
- research article
- Published by American Society for Microbiology in Applied and Environmental Microbiology
- Vol. 36 (6) , 794-797
- https://doi.org/10.1128/aem.36.6.794-797.1978
Abstract
The sensitivity of a polA strain to the antibacterial activity of mutagens and carcinogens may be increased by inserting one or both of the following characteristics, a lexA mutation or the R391 bacterial plasmid. The effects of the lexA mutation and the plasmid appear to be additive. The differential sensitivity of a polA lexA (R391) strain could be adapted as a preliminary screening test for mutagens and potential carcinogens.This publication has 16 references indexed in Scilit:
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