Studies on the Chemical Structure of Colistin
- 1 August 1964
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Biochemistry
- Vol. 56 (2) , 182-189
- https://doi.org/10.1093/oxfordjournals.jbchem.a127976
Abstract
The full structure of colistin B was determined as IOA→(α)DAB→Thr→(α)DAB→(α) cyclo→(γ)DAB→(α)DAB→D-Leu→L-Leu→(α)DAB→(α)DAB→Thr→ with combination of enzymatic digestion and acid partial hydrolysis. The structure is identical to that of colistin A, with the exception that colistin B contains isoöctanoic acid instead of 6-methyl-octanoic acid in colistin A.Keywords
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