High-Pressure Liquid Chromatographic Assay of Azlocillin and Mezlocillin with an Anion-Exchange Extraction Technique
- 1 November 1983
- journal article
- research article
- Published by Taylor & Francis in Journal of Liquid Chromatography
- Vol. 6 (13) , 2513-2520
- https://doi.org/10.1080/01483918308064918
Abstract
An anion-exchange column deproteination technique has been employed with the high-pressure liquid chromatographic (LC) assay for azlocillin and mezlocillin. The anionexchange extraction gave excellent (97%-99%) drug recovery. Quantitation of antibiotics using the LC method compares favorably to the traditional biological assay technique with correlation coefficients for azlocillin = 0.998 and mezlocillin = 0.988. The anion-exchange extraction provides an interference-free chromatogram which aids in the LC assay of these drugs.This publication has 5 references indexed in Scilit:
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