Phenothiazines and Sudden Infant Death Syndrome

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Abstract
A relationship between sudden infant death syndrome (SIDS), sleep apnea and upper airway infections is reported. The present observation stresses the possible influence of phenothiazine-containing medications and the occurrence of SIDS. The drug is commonly used for the treatment of infants with nasopharyngitis. In a prospective study, 52 SIDS victims, 36 near-miss infants and 175 control infants were compared for the coexistence of nasopharyngitis and phenothiazine treatment in the days preceding death or hospitalization. The incidence of nasopharyngitis was comparable in the 3 groups (.apprx. 31%), but phenothiazines were used significantly more frequently in SIDS victims (23%) and near-miss infants (22%) than in control subjects (2%). Phenothiazines, as CNS depressors, may contribute to the occurrence of SIDS.

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