Neutralization of SK Murine Poliomyelitis Virus and of Theiler's Virus of Mouse Encephalomyelitis by Human Sera

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Abstract
Among a total of 167 human sera, normal or convalescent, which were examined for their ability to neutralize SK murine poliomyelitis virus in intraperitoneal tests in albino mice, 11 were found to neutralize this virus. All of these neutralizing sera occurred in a group of 102 normal sera obtained from urban residents. 30 normal human sera were examined for their ability to neutralize Theiler''s virus of mouse encephalomyelitis in intracerebral tests in albino mice; none showed any neutralizing power. Among 100 normal human sera obtained from urban residents, which were examined for their ability to neutralize Theiler''s virus in intraperit. tests in albino mice, 9 were found to neutralize this virus. The significance of the above findings is discussed in the light of the available data on the neutralization of simian and murine strains of poliomyelitis virus by human sera.

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