ABNORMAL CHROMOSOMES AND NUMBER-1 HETEROCHROMATIN VARIANTS REVEALED IN C-BANDED PREPARATIONS FROM 13 BLADDER CARCINOMAS

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 18  (70) , 101-109
Abstract
The chromosomes of 13 carcinomas of the bladder were studied in C- and G-banded preparations. Heteromorphism for the amount of centromeric heterochromatin on the no. 1 chromosomes was apparent in 8 tumors, and in 3 of these heteromorphism was also found in the patient''s normal cells. In 4 tumors, there were pericentric inversions of the heterochromatic regions of 1 or more no. 1 chromosomes. Major structural changes involving no. 1 chromosomes appeared to have occurred in at least 7 tumors. In addition to the high incidence of heterochromatin variants (known or presumed to be constitutional phenomena), and major structural changes involving the no. 1 chromosomes, a further feature, common to 4 tumors, was the presence of a heterochromatic minute.

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