Changes in the sensitivity of left atrial receptors following reversal of heart failure

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Abstract
Recordings were made from left atrial type B receptors in 6 mongrel dogs after recovery from the cardiac effects of a chronic AV [arteriovenous] fistula. All animals showed hemodynamic and clinical signs of congestive heart failure after 44.5 .+-. 3.6 days with a patent Dacron shunt between the aorta and inferior vena cava below the level of the renal arteries. The stimulus-response curves of the left atrial stretch receptors (change in spikes/ cardiac cycle or in spikes/min vs. change in left atrial pressure) after 45.2 .+-. 7.2 days of shunt closure were similar to those seen in sham-operated dogs. The slope of the stimulus-response curve of the dogs in which the AV fistula was closed was significantly greater than the slope of the curve from the AV fistula dogs with heart failure. Radiographs indicated that after shunt closure, cardiac dilatation had regressed. A decrease in the sensitivity of left atrial receptors in dogs with congestive heart failure is a reversible phenomenon and that the initial depression is most likely related to the concomitant cardiac dilatation that accompanies the failure state.

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