Electrophoretic Determination of C-Reactive Protein Which Appears Following Surgery.
- 1 October 1962
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 111 (1) , 25-30
- https://doi.org/10.3181/00379727-111-27695
Abstract
A study was made of the sera of surgical patients in which preoperative serum was negative for C-reactive protein (CRP) and postoperative serum was strongly CRP-positive. In all cases there was a marked elevation in the alpha globulin fraction of the positive postoperative serum. When the CRP was removed from the postoperative serum, there was a significant reduction in alpha globulin, chiefly in the alpha 1 globulin fraction. When this CRP-positive serum was fractionated with ammonium sulfate, the fraction containing CRP contained no gamma globulin. It was concluded that CRP which appears following surgery is an alpha globulin.Keywords
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