The Effect of a Diphosphonate on Uremic Hyperparathyroidism

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Abstract
Chronic renal failure in the rat was shown to be associated with parathyroid enlargement, a decreased ash content of the femoral shaft and elevated trabecular bone resorption. The diphosphonate, ethane-1 -hydroxy-1,1-diphosphonate was ineffectual in the dose used in altering the manifestation of hyperparathyroidism even though more of the compound was retained in the skeleton of the uremic animals than in the controls.

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