Diethylstilbestrol Induces Neoplastic Transformation Without Measurable Gene Mutation at Two Loci
- 19 June 1981
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 212 (4501) , 1402-1404
- https://doi.org/10.1126/science.6262919
Abstract
The frequency with which diethylstilbestrol induces neoplastic transformation and somatic mutation was measured concomitantly in Syrian hamster embryo cells. While diethylstilbestrol was as active as benzo[a]pyrene in inducing transformation, it failed to induce mutations at two conventionally studied loci. These results suggest that diethylstilbestrol may transform cells in the absence of gene mutations.This publication has 12 references indexed in Scilit:
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