Acute Tumor Lysis in T-Cell Leukemia Induced by Amsacrine
- 1 January 1983
- journal article
- case report
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 143 (1) , 165-166
- https://doi.org/10.1001/archinte.1983.00350010177034
Abstract
• The acridine orange derivative amsacrine (National Services Center No. 249992) was used to treat a patient with T-cell acute lymphoblastic leukemia (ALL). A 17-year-old boy had a tumor lysis syndrome after a single 200 mg/sq m dose of amsacrine. This was followed by a prolonged period of marrow hypoplasia leading to death from infection. Review of the literature and our own experience would suggest that T-cell ALL may be exquisitely sensitive to amsacrine. (Arch Intern Med 1983;143:165-166)Keywords
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