4-Amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide, a new, potent fasciolicide
- 1 September 1977
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 20 (9) , 1225-1227
- https://doi.org/10.1021/jm00219a025
Abstract
Synthesis and fasciolicidal activity of 4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide are reported. A single dose of 15 mg/kg was effective in removing over 90% of immature Fasciola hepatica from sheep (6 wk after infection) and calves (8 wk after infection). A 2.5 mg/kg dose removed over 90% of mature (16 wk old) liver fluke from sheep. Single oral doses up to 400 mg/kg were tolerated by sheep without gross toxic symptoms.This publication has 2 references indexed in Scilit:
- The Efficacy of 4-Amino-6-Trichloroethenyl-1,3-Benzenedisulphonamide Against Liver Fluke in Sheep and CattleBritish Veterinary Journal, 1977
- Synthesis and Diuretic Activity of 3,3-Spiro-Substituted HydrothiazidesJournal of Medicinal Chemistry, 1962