SOME IMMUNOCHEMICAL PROPERTIES OF PENICILLENIC ACID
Open Access
- 1 December 1960
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 112 (6) , 1227-1247
- https://doi.org/10.1084/jem.112.6.1227
Abstract
Under mild conditions, benzylpenicillin in aqueous solution rearranges to benzylpenicillenic acid, which reacts, under suitable conditions, to form stable disulfides and mercaptides. Through reaction with native proteins or especially with proteins that are enriched in SH groups ("thiolated"), penicillenic acid forms, ma mixed disulfide linkages, stable highly substituted conjugates.Keywords
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