Virus Particles in Primordial Germ Cells of Fetal Guinea Pigs2
- 1 February 1974
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 52 (2) , 545-551
- https://doi.org/10.1093/jnci/52.2.545
Abstract
Virus particles morphologically similar to those observed in cells from leukemic and normal guinea pigs were found in the primordial germ cells of fetuses from non leukemic, randombred guinea pigs. The spherical particles were 85–110 mμ in diameter and had 2 electrondense shells surrounding a less dense core. They acquired their outer shell by budding into cisternae of the endoplasmic reticulum, and had a definite layer separating this membranous envelope from the inner shell. Filamentous projections were associated with the outer envelope. The relationship of these particles to described guinea pig leukemia viruses and the possible significance of this observation to vertical transmissi on of these viruses were discussed.Keywords
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