Anti-inflammatory constituents of topically applied crude drugs. II. Constituents and anti-inflammatory effect of Cryptomeria japonica D. DON.
- 1 January 1988
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 36 (10) , 3967-3973
- https://doi.org/10.1248/cpb.36.3967
Abstract
The ether-soluble fraction of MeOH extract from the leaves of Cryptomeria japonica D. Don showed an anti-inflammatory effect when topically applied to rats and an inhibitory effect on histamine-induced ileum contraction. The active component was isolated and identified as cis-communic acid (1). Two new diterpenoids were also isolated along with two known compounds and were determined to be imbricataloic acid dimethyl acetal (5) and (E)-13-hydroxylabda-8(17),11,14-trien-19-oic acid, obtained as the methyl ester (6m), by chemical and spectroscopic methods.This publication has 5 references indexed in Scilit:
- Anti-inflammatory constituents of topically applied crude drugs. I. Constituents and anti-inflammatory effect of Eriobotrya japonica Lindl.CHEMICAL & PHARMACEUTICAL BULLETIN, 1986
- Tobacco Chemistry. 43. Sensitized Photo-oxygenation of (12Z)-Abienol. Biomimetic Synthesis of Tobacco Labdanoids.Acta Chemica Scandinavica, 1978
- Diterpene—VTetrahedron, 1968
- The Chemistry of the Order Araucariales. Part 4. The Bled Resins of Agathis australis.Acta Chemica Scandinavica, 1966
- Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory DrugsExperimental Biology and Medicine, 1962