BLOOD-GROUP ANTIGENS MAY BE THE RECEPTORS FOR SPECIFIC DRUG-ANTIBODY COMPLEXES REACTING WITH RED-BLOOD-CELLS

  • 1 January 1983
    • journal article
    • research article
    • Vol. 296  (15) , 693-696
Abstract
Antibodies (19) specific for 11 different drugs [penicillin, nomifensine, ajmaline, triamterene, glafenine, Contrix, rifampicin, teniposide, catergen, ellipticine, moxalactam] were extensively tested in the presence of the drug against a panel of [human] red cells including common and public minus phenotypes. High incidence blood group antigens were specific receptors for several drug-antibody complexes suggesting that red blood cells play more than an innocent bystnder role in the drug-induced immune hemolytic anemias.

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