Mechanical Response Properties of A and C Primary Afferent Neurons Innervating the Rat Intracranial Dura
Open Access
- 1 December 2002
- journal article
- Published by American Physiological Society in Journal of Neurophysiology
- Vol. 88 (6) , 3021-3031
- https://doi.org/10.1152/jn.00029.2002
Abstract
The intracranial dura receives a small-fiber sensory innervation from the trigeminal ganglion that is thought to be involved in some types of headaches, including migraine. Mechanical response properties of dural afferent neurons were examined to investigate variation across the population in the properties of threshold, slope, adaptation, and incidence of mechanosensitivity. Dural afferent neurons were recorded in the trigeminal ganglion of urethan-anesthetized rats and were identified by their constant-latency response to dural shock. Neurons were classified as fast A (>5 m/s), slow A (5 ≥ conduction velocity (CV) ≥ 1.5 m/s), or C (Keywords
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