Hypoxia‐sensitive NMR contrast agents
- 1 February 1986
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 3 (1) , 169-174
- https://doi.org/10.1002/mrm.1910030126
Abstract
The rate of reduction of nitroxides is shown to be more rapid in hypoxic cells. The rate of reduction and the effect of hypoxia on the reduction rate vary for different nitroxides. These findings indicate that it may be feasible to develop in vivo NMR contrast agents that selectively will indicate areas of hypoxia and thereby aid in the detection of disease processes such as neoplasia, ischemia, and inflammation. © 1986 Academic Press, Inc.This publication has 17 references indexed in Scilit:
- Differences in the reduction kinetics of incorporated spin labels in undifferentiated and differentiated mouse neuroblastoma cellsBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1985
- Measurement of intracellular oxygen concentration using the spin label TEMPOLMagnetic Resonance in Medicine, 1985
- Influerce of chemical structure of nitroxyl spin labels on their reduction by ascorbic acidTetrahedron, 1985
- Relaxation of solvent protons by paramagnetic ions and its dependence on magnetic field and chemical environment: implications for NMR imagingMagnetic Resonance in Medicine, 1984
- Pharmacokinetics of Nitroxide NMR Contrast AgentsInvestigative Radiology, 1984
- Studies of factors affecting the design of NMR contrast agents: manganese in blood as a model systemMagnetic Resonance in Medicine, 1984
- Paramagnetic contrast agents in nuclear magnetic resonance medical imagingSeminars in Nuclear Medicine, 1983
- Surface localization of sites of reduction of nitroxide spin-labeled molecules in mitochondria.Proceedings of the National Academy of Sciences, 1977
- Ready reduction of some nitroxide free radicals with ascorbic acidJournal of the Chemical Society, Chemical Communications, 1977
- Novel Transfer Reactions of a Nitroxyl-Labeled Phosphoryl MoietySynthesis, 1977