Dietary citric acid enhances absorption of aluminum in antacids.
Open Access
- 1 March 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 32 (3) , 539-541
- https://doi.org/10.1093/clinchem/32.3.539
Abstract
Ten healthy men ingested, twice daily between meals, during each of the seven-day experimental periods: (a) citric acid (as lemon juice), (b) Al(OH)3, or (c) Al(OH)3 + citric acid. Whole blood sampled after each dietary period was analyzed electrothermally after digestion with nitric acid. Moderate, but significant, increases in mean Al concentrations as compared with pretreatment values [5 (SD 3) micrograms of Al per liter] were seen after ingestion of either citric acid or Al(OH)3: 9 (SD 4) and 12 (SD 3) micrograms/L, respectively. Ingestion of both Al(OH)3 and citric acid resulted in a more pronounced, highly significant (p less than 0.001) increase in Al concentrations, to 23 (SD 2) micrograms Al/L, probably owing to formation and absorption of Al-citrate complexes.This publication has 2 references indexed in Scilit:
- Controlled Clinical Trial of Duodenal Ulcer Healing with Antacid TabletsScandinavian Journal of Gastroenterology, 1982
- Gastrointestinal Absorption of Aluminum from Aluminum-Containing AntacidsNew England Journal of Medicine, 1977