Early Histopathology of the Cutaneous Capillary Fragility Test (Rumpel‐Leede)

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Abstract
The characteristic histologic changes seen at 2 h in the Rumpel-Leede (Hess) test are focal hemorrhage in the upper dermis and perivascular lymphocyte infiltration with focal areas of lymphocytic epidermal invasion. Histologic findings, even with liquefaction degeneration, are similar to those of purpura simplex and indicate that early in many forms of vasopermeability the lymphocyte may be a primary inflammatory cell.