Can Animal Models of Disease Reliably Inform Human Studies?
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Open Access
- 30 March 2010
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLoS Medicine
- Vol. 7 (3) , e1000245
- https://doi.org/10.1371/journal.pmed.1000245
Abstract
H. Bart van der Worp and colleagues discuss the controversies and possibilities of translating the results of animal experiments into human clinical trials.Keywords
This publication has 54 references indexed in Scilit:
- Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of EfficacyPLoS Biology, 2010
- Launching invasive, first‐in‐human trials against Parkinson's disease: Ethical considerationsMovement Disorders, 2009
- Systematic Review of the Empirical Evidence of Study Publication Bias and Outcome Reporting BiasPLOS ONE, 2008
- Translating animal research into clinical benefitBMJ, 2007
- Comparison of treatment effects between animal experiments and clinical trials: systematic reviewBMJ, 2006
- 1,026 Experimental treatments in acute strokeAnnals of Neurology, 2006
- Effect of Intravenous Recombinant Tissue Plasminogen Activator on Ischemic Stroke Lesion Size Measured by Computed TomographyStroke, 2000
- Recommendations for Standards Regarding Preclinical Neuroprotective and Restorative Drug DevelopmentStroke, 1999
- Infarct Volume as a Surrogate or Auxiliary Outcome Measure in Ischemic Stroke Clinical TrialsStroke, 1999
- Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trialsJAMA, 1995