Coagulation Studies in the Newborn Period

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Abstract
In a previous publication1and in the preceding paper2we have presented evidence indicating that the serum of newborns with hypoprothrombinemia has a marked deficit of another thromboplastic substance besides PTC. Moreover, in mixture experiments with the thromboplastin generation test and the Loeliger-Koller technique for determination of proconvertin, newborns with severe hypoprothrombinemia appeared to have the same defect as patients receiving prolonged treatment with coumarin compounds. The various deficits of these newborns were corrected by means of stored normal serum.1,2 The recently described Stuart factor3,4is a stable substance adsorbed by barium sulfate, which participates in the first and probably in the second stage of blood coagulation. Its deficiency is associated with a low thromboplastic activity of the serum and a very prolonged one-stage prothrombin time. The use of Russell viper venom (Stypven) also gives an abnormal result. The determination of proconvertin with a substrate plasma

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