A Randomized Factorial Trial of Vitamins C and E and Beta Carotene in the Secondary Prevention of Cardiovascular Events in Women
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Open Access
- 13 August 2007
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 167 (15) , 1610-1618
- https://doi.org/10.1001/archinte.167.15.1610
Abstract
Oxidative damage may play a role in the development of cardiovascular disease (CVD), particularly through its effect on lipid peroxidation and DNA damage.1 In addition, free radicals may damage arterial endothelium, encourage thrombosis, and alter vasomotor function.2 Antioxidants scavenge free radicals and limit the damage they can cause.3 Diets high in fruit and vegetable intake, and thus rich in such antioxidants, have been associated with reduced rates of coronary heart disease and stroke.4Keywords
This publication has 37 references indexed in Scilit:
- Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary PreventionJAMA, 2007
- Fruit and Vegetable Consumption and Risk of Coronary Heart Disease: A Meta-Analysis of Cohort StudiesJournal of Nutrition, 2006
- Calcium plus Vitamin D Supplementation and the Risk of FracturesNew England Journal of Medicine, 2006
- Plasma carotene and α-tocopherol in relation to 10-y all-cause and cause-specific mortality in European elderly: the Survey in Europe on Nutrition and the Elderly, a Concerted Action (SENECA)The American Journal of Clinical Nutrition, 2005
- Failure of Vitamin E in Clinical Trials: Is Gamma-Tocopherol the Answer?Nutrition Reviews, 2005
- Simvastatin and Niacin, Antioxidant Vitamins, or the Combination for the Prevention of Coronary DiseaseNew England Journal of Medicine, 2001
- Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general PracticeThe Lancet, 2001
- Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): randomised placebo-controlled trialThe Lancet, 2000
- Vitamin E Supplementation and Cardiovascular Events in High-Risk PatientsNew England Journal of Medicine, 2000
- β-Carotene Supplementation and Incidence of Cancer and Cardiovascular Disease: the Women's Health StudyJNCI Journal of the National Cancer Institute, 1999