Decarboxylation of S-Adenosyl-L-methionine in Vitamin B6 Deficiency in Rat Liver.

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Abstract
The effect of a prolonged diet deficient in B6-vitamin on the activity of adenosylmethionine decarboxylase [EC 4.1.1.50] from rat liver was investigated. Adenosylmethionine decarboxylase activity was not decreased under these restricted nutritional conditions. The addition of pyridoxal phosphate into the standard incubation mixture did not stimulate the activity of adenosylmethionine decarboxylase from the livers of the rats fed the B6-vitamin deficient diet. The contradictory results of Sturman and Kremzner might be based on an artificial liberation of CO2 from S-adenosyl-L-methionine in the presence of pyridoxal phosphate. The results of this communication do not support the view that pyridoxal phosphate acts as the prosthetic group of rat liver adenosylmethionine decarboxylase.