The Effects of Pindolol and Prazosin on Hand Blood Flow in Patients with cold Extremities and on Treatment with β‐Blockers

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Abstract
Hand blood flow and subjective sensitivity to cold were studied in 9 hypertensive patients on treatment with .beta.-blockers. All patients complained of cold extremities. Neither hand blood flow nor sensitivity to cold changed after addition of prazosin, a well known vasodilator, to the original .beta.-blocker. After changing to a .beta.-blocker with a high degree of intrinsic sympathomimetic activity (pindolol), hand blood flow increased and sensitivity to cold decreased in all patients, except 1.