[Modification of intracranial pressure by urapidil following experimental cold lesions in the cat].

  • 1 August 1986
    • journal article
    • abstracts
    • Vol. 21  (4) , 218-22
Abstract
The action of the antihypertensive agent Urapidil was investigated in an experimental animal model of vasogenic brain oedema. Animals with normal or raised intracranial pressure received Urapidil as a bolus injection (0.25 mg/kg body weight) followed by a continuous infusion of Urapidil (1 mg/kg body weight). The bolus injection of the drug was followed by a sharp fall in systemic blood pressure, paralleled by a rise in intracranial pressure, resulting in a shortlasting decline of cerebral perfusion pressure. During continuous infusion of Urapidil in both groups with normal or elevated ICP there was a long-lasting significant fall in the systemic blood pressure without any significant alteration of the intracranial pressure.

This publication has 0 references indexed in Scilit: