AN EFFICIENT METHOD FOR THE SYNTHESIS OF PEPTIDES BY THE USE OF PHENYLPHOSPHONIC ESTERS
- 5 November 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 8 (11) , 1305-1308
- https://doi.org/10.1246/cl.1979.1305
Abstract
Treatment of the tetrabutylammonium salt of N-benzoyl-L-leucine and glycine ethyl ester with bis(o- or p-nitrophenyl) phenylphosphonate in DMF resulted in the formation of the corresponding dipeptide in excellent yield with high optical purity. Similarly, racemization-free Z-L-Phe-Gly-OEt was prepared in high yield.Keywords
This publication has 4 references indexed in Scilit:
- Phosphorus in organic synthesis—XI Amino acids and peptides—XXITetrahedron, 1976
- Amino Acids and Peptides. XI. Phosphorus in Organic Synthesis. VI. Application of Diphenyl Phosphorazidate to the Synthesis of Peptides containing Various FunctionsCHEMICAL & PHARMACEUTICAL BULLETIN, 1974
- Diphenylphosphoryl azide. New convenient reagent for a modified Curtius reaction and for peptide synthesisJournal of the American Chemical Society, 1972
- The Use of Diester Chlorophosphites in Peptide Syntheses. Mixed Anhydrides1Journal of the American Chemical Society, 1952