The Biosynthetic Origins of Rebeccamycin

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Abstract
Experimental evidence is presented to demonstrate that the antitumor-antibiotic rebeccamycin is biosynthesized by Saccharothrix aerocolonigenes from one unit of glucose, one of methionine, and two of tryptophan. Evidence is presented that suggests that the .alpha.-amino group of neither tryptophan unit provides the nitrogen of the phthalimide system.

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