ADRENERGIC LIGAND LIPOSOLUBILITY IN MEMBRANES - DIRECT ASSESSMENT IN A BETA-ADRENERGIC BINDING SYSTEM

  • 1 January 1982
    • journal article
    • research article
    • Vol. 22  (1) , 5-7
Abstract
The binding of [3H]dihydroalprenolol to adipocyte membranes may be displaced not only from .beta.-adrenergic receptors but also nonstereospecifically from other membrane compartments by .beta.-adrenergic and other adrenergic agents. The EC50 [median effective concentration] of this nonstereospecific displaceable binding is directly related to the liposolubility (n-octanol:water partition coefficient) of the displacing ligand.

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