Effects of GABAergic Drugs In Vivo on High-Affinity Choline Uptake In Vitro in Mouse Hippocampal Synaptosomes
- 1 December 1986
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 47 (6) , 1916-1918
- https://doi.org/10.1111/j.1471-4159.1986.tb13107.x
Abstract
The effects of several .gamma.-aminobutyric acid (GABA)-ergic drugs on sodium-dependent high-affinity choline uptake (HACU) were investigated in the hippocampus. HACU was measured in vitro administration of the drug to mice. HACU was inhibited by those drugs that enhance GABA transmission. The convulsant 3-mercaptopropionic acid, which decreases GABA levels, stimulated HACU. From these results and previous findings, it appears that GABA mediates a tonic inhibitor effect on the septal-hippocampal cholinergic system.Keywords
This publication has 11 references indexed in Scilit:
- An immunohistochemical study on the location of GABAergic neurons in rat septumJournal of Comparative Neurology, 1984
- High‐Affinity Choline Uptake in the Hippocampus: Its Relationship to the Physiological State Produced by Administration of Barbiturates and Other TreatmentsJournal of Neurochemistry, 1982
- Effect of γ-vinyl GABA on bicuculline-induced seizuresNeuropharmacology, 1981
- MUSCIMOL AS AN ANTAGONIST OF CHEMICAL CONVULSANTS1981
- THE SEPTAL-HIPPOCAMPAL CHOLINERGIC PATHWAY - ROLE IN ANTAGONISM OF PENTOBARBITAL-ANESTHESIA AND REGULATION BY VARIOUS AFFERENTS1981
- Interaction between GABA agonists and the cholinergic muscarinic system in rat corpus striatumLife Sciences, 1980
- An investigation of whether septal γ-aminobutyrate-containing interneurons are involved in the reduction in the turnover rate of acetylcholine elicited by substance P and β-endorphin in the hippocampusNeuroscience, 1979
- SODIUM‐DEPENDENT HIGH AFFINITY CHOLINE UPTAKE: A REGULATORY STEP IN THE SYNTHESIS OF ACETYLCHOLINEJournal of Neurochemistry, 1976
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951